abstract：:Patients with HPV-positive and HPV-negative head and neck squamous cell carcinoma (HNSCC) are significantly different with regard to sociodemographic and behavioral characteristics that clinicians may use to assume tumor HPV status. Machine learning methods were used to evaluate the predictive value of patient charact...

journal_title：Oral oncology

authors： D'Souza G,Zhang HH,D'Souza WD,Meyer RR,Gillison ML

更新日期：2010-02-01 00:00:00

abstract：:The zebrafish has become a useful model organism for research on development and diseases. However, there has been no zebrafish model system for studying oral carcinogenesis. In the present study, we first characterized the histology of the upper gastrointestinal tract of zebrafish. We found that zebrafish tongue was ...

journal_title：Oral oncology

authors： Hu B,Zhang C,Baawo K,Qin R,Cole GJ,Lee JA,Chen X

更新日期：2010-01-01 00:00:00

abstract：:The aim of this study was to estimate the relations between hypoxia inducible factor-1alpha (HIF-1alpha) gene polymorphisms, C1772T and G1790A, to the susceptibility and clinicopathological status of oral cancer. A total of 521 subjects, including 347 controls and 174 oral cancer patients, were recruited in this study...

journal_title：Oral oncology

authors： Chen MK,Chiou HL,Su SC,Chung TT,Tseng HC,Tsai HT,Yang SF

更新日期：2009-12-01 00:00:00

abstract：:The history of mucositis is as old as radiation- and chemotherapy. Despite being regularly reported and documented as one of the worst side effects of cancer therapy, relatively little was appreciated about the complexities of mucositis' pathogenesis until relatively recently. More frustrating for patients and clinici...

journal_title：Oral oncology

authors： Sonis ST

更新日期：2009-12-01 00:00:00

abstract：:Preoperative elevation of serum C-reactive protein (CRP) has been demonstrated as a prognostic indicator in oesophageal, gastric and colorectal cancer. This study was designed to establish if elevated preoperative levels of serum CRP could predict the prognosis of patients treated with primary surgery for oral squamou...

journal_title：Oral oncology

authors： Khandavilli SD,Ceallaigh PO,Lloyd CJ,Whitaker R

更新日期：2009-10-01 00:00:00

abstract：:Vocal process granulomas are benign lesions involved in the healing of posterior glottis injuries. Here, we report the results of our conservative treatment of vocal process granulomas. Fifty-three patients with 54 occurrences of granulomas between 1998 and 2007 were enrolled. All patients were observed without surgic...

journal_title：Oral oncology

authors： Wang CP,Ko JY,Wang YH,Hu YL,Hsiao TY

更新日期：2009-09-01 00:00:00

abstract：:Comorbidity and diagnostic delay are independent prognostic factors in head and neck cancer, most notably in laryngeal cancer. We investigated their inter-relationship and their relative significance in survival of three different head and neck cancers. A population-based retrospective cohort of 221 patients with canc...

journal_title：Oral oncology

authors： Teppo H,Alho OP

更新日期：2009-08-01 00:00:00

abstract：:Human beta-defensins (hBDs) are small, cationic antimicrobial peptides produced by oral and other mucosal epithelia. More recently, hBDs have been shown to regulate adaptive immunity. In this study, we provide new information about the potential role of hBD-3 in the progression of oral cancer. In normal human oral epi...

journal_title：Oral oncology

authors： Kawsar HI,Weinberg A,Hirsch SA,Venizelos A,Howell S,Jiang B,Jin G

更新日期：2009-08-01 00:00:00

abstract：:Conventional surgical approaches for tonsillar carcinomas have a great risk for developing treatment-related morbidity. To minimize this morbidity, transoral lateral oropharyngectomy (TLO) using the robotic surgical system was performed, and the efficacy and feasibility of this procedure was evaluated. TLO was perform...

journal_title：Oral oncology

authors： Park YM,Lee JG,Lee WS,Choi EC,Chung SM,Kim SH

更新日期：2009-08-01 00:00:00

abstract：:Odontogenic keratocyst (OKC) has an aggressive clinical course and a high tendency toward recurrence, while orthokeratinized odontogenic cyst has different characteristics and does not show aggressive behavior. Bax and bcl-2 are two important anti-apoptotic and pro-apoptotic factors of the bcl-2 family. The different ...

journal_title：Oral oncology

authors： Rangiani A,Motahhary P

更新日期：2009-07-01 00:00:00

abstract：:EGFR overexpression in salivary gland carcinomas provides the rational for the investigation of anti-EGFR treatments in recurrent and/or metastatic salivary gland cancers (RMSGCs). The activity of cetuximab in terms of clinical benefit rate (CBR) defined as the occurrence of objective response (CR or PR) or stable dis...

journal_title：Oral oncology

authors： Locati LD,Bossi P,Perrone F,Potepan P,Crippa F,Mariani L,Casieri P,Orsenigo M,Losa M,Bergamini C,Liberatoscioli C,Quattrone P,Calderone RG,Rinaldi G,Pilotti S,Licitra L

更新日期：2009-07-01 00:00:00

abstract：:Incidence of oropharyngeal squamous cell carcinoma (OSCC) increased 3% annually from 1973 to 2001. OSCC's can be attributed to tobacco and alcohol, but 25% are unlinked to typical risks. Case-control studies on HPV detection in non-smoking/non-drinking (NS/ND) OSCC patients have not previously been performed. The prim...

journal_title：Oral oncology

authors： Andrews E,Seaman WT,Webster-Cyriaque J

更新日期：2009-06-01 00:00:00

abstract：:It is well known that cellular DNA alterations can lead to the formation of cancer, and there has been much discovery in the pathways involved in the development of head and neck squamous cell carcinoma (HNSCC). With novel genome-wide molecular assays, our ability to detect these abnormalities has increased. We now ha...

journal_title：Oral oncology

authors： Ha PK,Chang SS,Glazer CA,Califano JA,Sidransky D

更新日期：2009-04-01 00:00:00

abstract：:Head and neck malignant tumors are classified according to the TNM staging system. The TNM system is a universally accepted, widely used, staging method. Its goals are to help clinicians and researchers to choose from treatment options, to give patients an estimate of their prognosis and to compare results of treatmen...

journal_title：Oral oncology

authors： van der Schroeff MP,Baatenburg de Jong RJ

更新日期：2009-04-01 00:00:00

abstract：:Cyclooxygenase-2 (COX-2) is overexpressed in various types of human malignancies, including oral cancers. Recent studies have shown that mast cell-derived protease tryptase can induce COX-2 expression by the cleavage of proteinase-activated receptor-2 (PAR-2). Actinic cheilitis (AC) is a premalignant form of lip cance...

journal_title：Oral oncology

authors： Rojas IG,Martínez A,Brethauer U,Grez P,Yefi R,Luza S,Marchesani FJ

更新日期：2009-03-01 00:00:00

abstract：:Primary oral melanoma (POM) is a rare form of melanoma, generally diagnosed at a late stage and has poor prognosis. Epidemiological information has scarcely been reported in the literature over the past 40 years. Analyzing the Cancer Incidence in Five Continents volume IX (CI5-IX) database we found a total of 124,436 ...

journal_title：Oral oncology

authors： Sortino-Rachou AM,Cancela Mde C,Voti L,Curado MP

更新日期：2009-03-01 00:00:00

abstract：:Hematogenous metastasis is one of the most important factors determining the outcome of the patients with salivary adenoid cystic carcinoma (SACC). In the present study, we examined expression profile of genes in SACC cell lines to look for molecules responsible for its unique metastatic trait. A transcriptomic microa...

journal_title：Oral oncology

authors： Hu K,Li SL,Gan YH,Wang CY,Yu GY

更新日期：2009-02-01 00:00:00

abstract：:The etiology of oral squamous cell carcinoma has been linked to environmental carcinogens, such as activated aromatic heterocyclic radicals and epoxides. Our previous work on implantable and 7,12-dimethylbenz[a]anthracene (DMBA)-induced breast cancer showed that oral glutamine (GLN) inhibited tumor growth possibly thr...

journal_title：Oral oncology

authors： Lim V,Korourian S,Todorova VK,Kaufmann Y,Klimberg VS

更新日期：2009-02-01 00:00:00

abstract：:The selection of housekeeping genes is critical for gene expression studies. To address this issue, four candidate housekeeping genes, including several commonly used ones, were investigated in oral squamous cell carcinoma cell lines. A simple quantitative RT-PCR approach was employed by comparing relative expression ...

journal_title：Oral oncology

authors： Campos MS,Rodini CO,Pinto-Júnior DS,Nunes FD

更新日期：2009-02-01 00:00:00

abstract：:The Wnt pathway is involved in carcinogenesis and three regulatory genes of the Wnt pathway, APC (adenomatous polyposis coli), beta-catenin and Axin are frequently mutated in some primary human cancers. This study was conducted to clarify the relation of beta-catenin accumulation and the mutation of the CTNNB1 (beta-c...

journal_title：Oral oncology

authors： Siriwardena BS,Kudo Y,Ogawa I,Tilakaratne WM,Takata T

更新日期：2009-02-01 00:00:00

abstract：:Epithelial cell adhesion molecule (EpCAM) is important for cell proliferation and differentiation but mechanisms regulating their expression are unclear. Because EpCAM may play a role in carcinogenesis, we investigated the clinicopathologic significance of its expression in oral squamous cell carcinoma (OSCC) and the ...

journal_title：Oral oncology

authors： Shiah SG,Chang LC,Tai KY,Lee GH,Wu CW,Shieh YS

更新日期：2009-01-01 00:00:00

abstract：:The recently identified single nucleotide polymorphism in the MDM2 promoter (SNP 309) may contribute to the early onset of both sporadic and hereditary malignancies in patients with defective p53. We tested this hypothesis by examining the effects of combined MDM2 polymorphisms and somatic p53 mutations on 351 oral sq...

journal_title：Oral oncology

authors： Huang SF,Chen IH,Liao CT,Wang HM,Liou SH,Hsieh LL

更新日期：2009-01-01 00:00:00

abstract：:The submental artery island flap (SIF) is gaining acceptance as a simple and reliable option in selected oral oncologic reconstructions. The present study aims to assess the usefulness of submental artery flap in oral reconstruction with respect to flap reliability, cosmesis, function, donor site morbidity and oncolog...

journal_title：Oral oncology

authors： Sebastian P,Thomas S,Varghese BT,Iype EM,Balagopal PG,Mathew PC

更新日期：2008-11-01 00:00:00

abstract：:The purpose of this study was to assess the accuracy of this tissue staining assessment of surgical specimens in delineating deep surgical margins in oral cancer surgery. Fifteen patients who underwent surgery for oral carcinoma were included in the study. Once the tumor was resected, a vertical section of the surgica...

journal_title：Oral oncology

authors： Kurita H,Sakai H,Kamata T,Koike T,Kobayashi H,Kurashina K

更新日期：2008-10-01 00:00:00

abstract：:The p53 pathway is commonly altered during oral and skin carcinogenesis. The lip is a transition tissue between skin and oral mucosa, which in response to UVB exposure also exhibits alterations in the expression of p53 and p53-related genes that could lead to malignant transformation. To assess if the p53-regulated pr...

journal_title：Oral oncology

authors： Martínez A,Brethauer U,Borlando J,Spencer ML,Rojas IG

更新日期：2008-09-01 00:00:00

abstract：:Oral leukoplakia is the most prevalent and potentially malignant disorder of the oral mucosa. Previous studies have demonstrated that molecular changes of the WWOX gene (WW-domain containing oxidoreductase), a candidate tumor suppressor gene located at 16q23.3-24.1 that spans FRA16D, the second most common fragile sit...

journal_title：Oral oncology

authors： Pimenta FJ,Cordeiro GT,Pimenta LG,Viana MB,Lopes J,Gomez MV,Aldaz CM,De Marco L,Gomez RS

更新日期：2008-08-01 00:00:00

abstract：:This hospital-based cohort study evaluated the efficacy of three Epstein-Barr virus (EBV) - associated assays for nasopharyngeal carcinoma (NPC) primary screening and monitoring treatment outcome. Five hundred and seventeen consecutive subjects, including 156 NPC patients, 264 healthy volunteers and 97 patients with h...

journal_title：Oral oncology

authors： Chang KP,Hsu CL,Chang YL,Tsang NM,Chen CK,Lee TJ,Tsao KC,Huang CG,Chang YS,Yu JS,Hao SP

更新日期：2008-08-01 00:00:00

abstract：:Oral lichen planus (OLP) is a chronic inflammatory disease and although classified by WHO as a premalignant condition, the risk for transformation into squamous cell carcinoma of the head and neck (SCCHN) is a matter of great controversy. The p63 gene encodes six different proteins which are required for development o...

journal_title：Oral oncology

authors： Ebrahimi M,Boldrup L,Wahlin YB,Coates PJ,Nylander K

更新日期：2008-07-01 00:00:00

abstract：:The semaphorins belong to a family of proteins originally shown to be important in axon migration and proper central nervous system development. Recent evidence has demonstrated that semaphorins and their receptors are expressed in tissues outside of the nervous system and represent a widespread signaling system that ...

journal_title：Oral oncology

authors： Sun Q,Nawabi-Ghasimi F,Basile JR

更新日期：2008-06-01 00:00:00

abstract：:Mucoepidermoid carcinoma is the most common malignant tumor in salivary glands and high-grade mucoepidermoid carcinoma is often accompanied with poor prognosis. Many recent research works demonstrated that stromal cell-derived factor-1 (SDF-1) and its receptor CXC chemokine receptor-4 (CXCR4) interaction was critical ...

journal_title：Oral oncology

authors： Wen DS,Zhu XL,Guan SM,Wu YM,Yu LL,Wu JZ

更新日期：2008-06-01 00:00:00

abstract：:Several lines of evidence demonstrated that the stroma surrounding the tumors plays an important role in the growth and progression of several neoplasms, including oral squamous cell carcinomas (OSCC). We evaluated the presence of myofibroblasts in OSCC and determined whether their presence is associated with clinicop...

journal_title：Oral oncology

authors： Kellermann MG,Sobral LM,da Silva SD,Zecchin KG,Graner E,Lopes MA,Kowalski LP,Coletta RD

更新日期：2008-05-01 00:00:00

abstract：:Adenocarcinoma of the minor salivary gland (MSG) is a rare neoplasm. It represents about 2% of all MSG malignant tumours. It is more common in the palate and in females. This tumour occurs in a mean age of sixty and its mean size at presentation is 1.5cm. Microscopically, the neoplasms classified as adenocarcinoma not...

journal_title：Oral oncology

authors： Moreno M,Moreno A,Tomé C

更新日期：2008-03-01 00:00:00

abstract：:Head and neck cancers during pregnancy are rising in incidence. Clinicians need to be aware of the principles of managing these cases. This paper is a review of the literature of head and neck cancers during pregnancy with a short case series of six non-thyroid pregnancy-associated cancers treated by a head and neck o...

journal_title：Oral oncology

authors： Atabo A,Bradley PJ

更新日期：2008-03-01 00:00:00

abstract：:Metallothioneins (MTs) are a family of low molecular weight, cysteine-rich, inducible, intracellular proteins that bind heavy metals with high affinity. MT-1 is known as a stress-inducible protein and functions as an antioxidant enzyme. Areca quid chewing is a major risk factor in the development and further progressi...

journal_title：Oral oncology

authors： Lee SS,Yang SF,Ho YC,Tsai CH,Chang YC

更新日期：2008-02-01 00:00:00

abstract：:Ameloblastoma is the most common odontogenic tumor. It can exhibit a variety of histological patterns, a great infiltrative potential and a high recurrence rate. Mutations in microsatellite sequences are a hallmark of neoplastic transformation but little is known about their role in ameloblastoma development. In this ...

journal_title：Oral oncology

authors： Migaldi M,Sartori G,Rossi G,Cittadini A,Sgambato A

更新日期：2008-01-01 00:00:00

abstract：:Betel quid (BQ) and matrix metalloproteinase-8 (MMP-8) play roles in oral diseases. Here, we analyzed the regulation of MMP-8 by BQ and its effect on cell migration. We found that BQ extract (BQE) increased the secretion of an 85kDa caseinolytic proteinase, specifically precipitated by an anti-MMP-8 antibody, in the c...

journal_title：Oral oncology

authors： Liu SY,Liu YC,Huang WT,Huang GC,Chen TC,Lin MH

更新日期：2007-11-01 00:00:00

abstract：:The present study was conducted to evaluate the therapeutic results of alternating chemoradiotherapy for locally advanced nasopharyngeal cancer. The subjects were 87 patients with stage II-IVB nasopharyngeal cancer. Alternating chemoradiotherapy was performed; initially, chemotherapy was administered, and then radioth...

journal_title：Oral oncology

authors： Fuwa N,Shikama N,Hayashi N,Matsuzuka T,Toita T,Yuta A,Oonishi H,Kodaira T,Tachibana H,Nakamura T,Daimon T

更新日期：2007-10-01 00:00:00

abstract：:Controversy remains about which patients at intermediate risk of recurrence of oral squamous cell carcinoma would benefit from radiotherapy. A retrospective review of computerised database and medical records for 462 consecutive patients at the Regional Maxillofacial Unit in Liverpool who were treated with primary sur...

journal_title：Oral oncology

authors： Brown JS,Blackburn TK,Woolgar JA,Lowe D,Errington RD,Vaughan ED,Rogers SN

更新日期：2007-09-01 00:00:00

abstract：:Recently, we reported the preliminary results of a prospective study on the possible premalignant character of oral lichen planus (OLP) and oral lichenoid lesions (OLL). Based on these data it was concluded that there was some but no convincing support for the hypothesis that patients with OLL have an increased risk o...

journal_title：Oral oncology

authors： van der Meij EH,Mast H,van der Waal I

更新日期：2007-09-01 00:00:00

abstract：:Adenoid cystic carcinoma (ACC) of the salivary glands exhibits persistent growth, invasion and metastasis. Chromosome 11q13 amplification is a frequent event associated with tumor progression in a number of carcinomas and is associated with poor prognosis. Two genes within the 11q13 amplicon that are overexpressed as ...

journal_title：Oral oncology

authors： Greer RO Jr,Said S,Shroyer KR,Marileila VG,Weed SA

更新日期：2007-09-01 00:00:00